New therapies Haemopoietic growth factors
نویسندگان
چکیده
Haemopoietic growth factors are involved in the production of the various blood cells from progenitors in the bone marrow, making them useful in a range of clinical situations. The genes for several of them have been cloned and their production engineered by recombinant technology, making them widely available. Myeloid growth factors are used to support patients in the aftermath of chemotherapy and bone marrow transplantation and have potential application in the treatment of infectious diseases. Erythropoietin is widely used for patients with anaemia due to failure of marrow production, having established its effectiveness in chronic renal failure. Thrombopoietin has recently been described and may provide a means to alleviate thrombocytopenia. Current indications and areas of recent reappraisal are addressed in this review.
منابع مشابه
Forty years at the pitface in the Walter and Eliza Hall Institute of Medical Research.
Donald Metcalf's contributions to the understanding of haemopoietic growth factors have led to the use of G-CSF and GM-CSF as valuable new therapies in medical oncology. We asked Professor Metcalf to reflect on his 40 years in medical research (most of it spent at the laboratory bench) and to give us his thoughts on the evolution of the Australian research effort.
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I!. Haemopoietic growth factors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 113 A. lnterleukin 3 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 113 I. Cells which respon.d to interleukin 3 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ....
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